HDAC6-IN-86
HDAC6-IN-86 is a histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 74 nM, and it exhibits high selectivity for HDAC1. HDAC6-IN-86 induces cell apoptosis, triggers G2/M phase cell cycle arrest, and inhibits the proliferation of glioma cells. HDAC6-IN-86 can be used for the research of glioblastoma multiforme (GBM).
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- CAS No.: 2271229-98-0
- Formule: C21H18N2O3S
- Masse moléculaire:378.44
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Activité biologique
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HDAC6 74 nM (IC50) |
HDAC6-IN-86 (Compound 6d) potently inhibits the proliferation of U87MG and U118MG glioblastoma cells, with IC50 values of 2.65 μM and 2.79 μM, respectively, while exhibiting low toxicity against normal LO2 hepatocytes (IC50 = 32.64 μM)[1].
HDAC6-IN-86 (1-27 μM; 24 h) induces dose-dependent apoptosis in U87MG glioblastoma cells[1].
HDAC6-IN-86 (1-27 μM; 24 h) induces dose-dependent G2/M cell cycle arrest in U87MG glioblastoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human glioblastoma U87MG cells
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Concentration:1, 3, 9 and 27 μM
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Incubation Time:24 h
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Result:Induced dose-dependent apoptosis in U87MG cells with total apoptotic rate of 7.78% at 1 μM.
Induced total apoptotic rate of 11.51% at 3 μM.
Induced total apoptotic rate of 17.49% at 9 μM.
Induced total apoptotic rate of 32.02% at 27 μM.
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Cell Line:human glioblastoma U87MG cells
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Concentration:1, 3, 9 and 27 μM
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Incubation Time:24 h
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Result:Induced dose-dependent G2/M phase cell cycle arrest in U87MG cells.
Arrested over 70% of cells in G2/M phase at 27 μM, with a corresponding decrease in the proportion of cells in G0/G1 phase.
Chemical Information
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CAS No. 2271229-98-0
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Masse moléculaire 378.44
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Formule C21H18N2O3S
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SMILES
O=C(NO)C(C=C1)=CC=C1CN2C3=CC=CC=C3SC4=C2C=C(OC)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-86 Related Classifications
HY-187210 Related Classifications
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