Oxonantenine
Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis.
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- CAS No.: 15358-38-0
- Formule: C19H13NO5
- Masse moléculaire:335.31
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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JNK3 |
Oxonantenine (8.15 μM; 48 h) potently inhibits the viability of A549 cells with an IC50 of 8.15 μM[1].
Oxonantenine potently binds to MAPK/NF-κB signaling pathway-related proteins (JUN, MAPK1, p38, MAPK3, ERK, JNK3, p65) with binding energies ranging from -33.39 to -44.61 kcal/mol, indicating stable target interactions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 15358-38-0
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Masse moléculaire 335.31
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Formule C19H13NO5
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SMILES
O=C1C2=NC=CC3=CC(OC)=C(C(C4=C1C=C5OCOC5=C4)=C23)OC
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Qin J, et al. Two new isoquinoline alkaloids from the seeds of Nandina domestica. Nat Prod Res. 2021 Oct;35(19):3254-3260. [Content Brief]
[2]. Zhang W, et al. Network Pharmacology-Based Strategy Integrated with Molecular Docking and In Vitro Experimental Validation to Explore the Underlying Mechanism of Decoction in Treating Rheumatoid Arthritis. ACS omega. 2024 Jul 23;9(29):31878-31889. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxonantenine Related Classifications
HY-N19654 Related Classifications
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