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Cat. No.: HY-165401

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SC 19886

SC 19886 is an inhibitor of Aldosterone (HY-113313) synthesis. SC 19886 blocks Aldosterone-induced DNA-dependent RNA synthesis. SC 19886 can be used in studies related to primary aldosteronism^[1]^[2].

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CAS No.: 22785-18-8
Formule: C₁₉H₂₆O₂
Masse moléculaire:286.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

SC 19886 Chemical Structure

CAS No.: 22785-18-8

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

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In Vitro

SC 19886 (infused at 0.1 mM) completely inhibits spontaneous aldosterone production in perfused Rana ridibunda frog adrenal interrenal fragments, and this irreversible effect persists for at least 7 h, while it also completely blocks the stimulatory effects of ACTH and angiotensin II on aldosterone biosynthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 22785-18-8
Masse moléculaire 286.41
Formule C₁₉H₂₆O₂
SMILES

C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@@]([C@H](C(CC4)=O)C)([H])C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Netchitailo P, et al. Relative inhibitory potency of five mineralocorticoid antagonists on aldosterone biosynthesis in vitro. Biochemical pharmacology. 1985 Jan 15;34(2):189-94. [Content Brief]

[2]. Porter GA, et al. The effect of a new anti-aldosterone agent SC19886 on aldosterone-stimulated transepithelial sodium transport. J Steroid Biochem. 1972 Feb;3(2):201-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
Chemical Information
Pureté et documentation
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SC 19886

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis