Capecitabine-2',3'-cyclic carbonate

Cat. No.: HY-W614957 Purity: 98.90%: Data Sheet
COA

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Handling Instructions
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Capecitabine-2',3'-cyclic carbonate (Compd 5a) is a 5'-deoxy-5-fluorocytidine derivative with anticancer activity.

For research use only. We do not sell to patients.

Capecitabine-2',3'-cyclic carbonate Chemical Structure

CAS No. : 921769-65-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Capecitabine-2',3'-cyclic carbonate:

Capecitabine-2',3'-cyclic carbonate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Capecitabine-2',3'-cyclic carbonate (Compd 5a) is a 5'-deoxy-5-fluorocytidine derivative with anticancer activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.08 mg/mL Compound: 5a	Cytotoxicity against human HeLa cells after 3 days MTT assay Cytotoxicity against human HeLa cells after 3 days MTT assay	[PMID: 22796042]
MCF7	IC₅₀	0.08 mg/mL Compound: 5a	Cytotoxicity against human MCF7 cells after 3 days MTT assay Cytotoxicity against human MCF7 cells after 3 days MTT assay	[PMID: 22796042]
NCI-H69	IC₅₀	0.18 mg/mL Compound: 5a	Cytotoxicity against human NCI-H69 cells after 3 days MTT assay Cytotoxicity against human NCI-H69 cells after 3 days MTT assay	[PMID: 22796042]

Molecular Weight

385.34

Formula

C₁₆H₂₀FN₃O₇

CAS No.

921769-65-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C=C(C(NC(OCCCCC)=O)=N1)F)[C@H]2[C@@]3([H])[C@@](OC(O3)=O)([H])[C@H](O2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (259.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5951 mL	12.9756 mL	25.9511 mL
5 mM	0.5190 mL	2.5951 mL	5.1902 mL
10 mM	0.2595 mL	1.2976 mL	2.5951 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.90%

Select Batch:

Data Sheet (268 KB) SDS (644 KB)

COA (248 KB) HNMR (497 KB) RP-HPLC (244 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. V. Jhansi Rani, et al. Synthesis and biological activity evaluation of cytidine-5′-deoxy-5-fluoro-N-[(alkoxy/aryloxy)] carbonyl-cyclic 2′,3′-carbonates.European Journal of Medicinal Chemistry.Volume 54, August 2012, Pages 690-696.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5951 mL	12.9756 mL	25.9511 mL	64.8778 mL
	5 mM	0.5190 mL	2.5951 mL	5.1902 mL	12.9756 mL
	10 mM	0.2595 mL	1.2976 mL	2.5951 mL	6.4878 mL
	15 mM	0.1730 mL	0.8650 mL	1.7301 mL	4.3252 mL
	20 mM	0.1298 mL	0.6488 mL	1.2976 mL	3.2439 mL
	25 mM	0.1038 mL	0.5190 mL	1.0380 mL	2.5951 mL
	30 mM	0.0865 mL	0.4325 mL	0.8650 mL	2.1626 mL
	40 mM	0.0649 mL	0.3244 mL	0.6488 mL	1.6219 mL
	50 mM	0.0519 mL	0.2595 mL	0.5190 mL	1.2976 mL
	60 mM	0.0433 mL	0.2163 mL	0.4325 mL	1.0813 mL
	80 mM	0.0324 mL	0.1622 mL	0.3244 mL	0.8110 mL
	100 mM	0.0260 mL	0.1298 mL	0.2595 mL	0.6488 mL