5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine
Based on 1 Customer Validation
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine (2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine) is an antiviral compound that inhibits HBV reverse transcriptase activity. 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine shows potential to control HBV replication in vitro. 5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine, as a nucleoside analog, may provide a new option for the suppression of chronic hepatitis B.
For research use only. We do not sell to patients.
- Purity : 99.77%
- CAS No.: 161599-46-8
- Formula: C13H16FN3O6
- Molecular Weight:329.28
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-B0016
Capecitabine -
HY-W105601R
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine (Standard) -
HY-17392
Zalcitabine -
HY-14905
Uridine triacetate -
HY-B0016R
Capecitabine (Standard) -
HY-W009538
5'-Deoxy-5-fluorocytidine -
HY-W009538R
5'-Deoxy-5-fluorocytidine (Standard) -
HY-W614957
Capecitabine-2',3'-cyclic carbonate -
HY-W014306
2',3'-Dideoxyuridine -
HY-17392R
Zalcitabine (Standard) -
HY-W099488
Capecitabine 2',3'-diacetate -
HY-W614957R
Capecitabine-2',3'-cyclic carbonate (Standard)
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
Chemical Information
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CAS No. 161599-46-8
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Appearance Solid
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Molecular Weight 329.28
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Formula C13H16FN3O6
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Color White to off-white
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SMILES
C[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2C=C(F)C(N)=NC2=O)O1
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Synonyms
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (303.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (7.59 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0369 mL | 15.1846 mL | 30.3693 mL | 75.9232 mL |
| 5 mM | 0.6074 mL | 3.0369 mL | 6.0739 mL | 15.1846 mL | |
| 10 mM | 0.3037 mL | 1.5185 mL | 3.0369 mL | 7.5923 mL | |
| 15 mM | 0.2025 mL | 1.0123 mL | 2.0246 mL | 5.0615 mL | |
| 20 mM | 0.1518 mL | 0.7592 mL | 1.5185 mL | 3.7962 mL | |
| 25 mM | 0.1215 mL | 0.6074 mL | 1.2148 mL | 3.0369 mL | |
| 30 mM | 0.1012 mL | 0.5062 mL | 1.0123 mL | 2.5308 mL | |
| 40 mM | 0.0759 mL | 0.3796 mL | 0.7592 mL | 1.8981 mL | |
| 50 mM | 0.0607 mL | 0.3037 mL | 0.6074 mL | 1.5185 mL | |
| 60 mM | 0.0506 mL | 0.2531 mL | 0.5062 mL | 1.2654 mL | |
| 80 mM | 0.0380 mL | 0.1898 mL | 0.3796 mL | 0.9490 mL | |
| 100 mM | 0.0304 mL | 0.1518 mL | 0.3037 mL | 0.7592 mL |
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine Related Classifications
HY-W105601 Related Classifications
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