Search Result
Results for "
carbazole
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
14
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-12451
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FICZ
Maximum Cited Publications
29 Publications Verification
6-Formylindolo[3,2-b]carbazole
|
Aryl Hydrocarbon Receptor
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Others
|
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FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.
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-
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- HY-15976
-
|
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Others
|
Neurological Disease
|
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P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole, with neuroprotective effects. P7C3 can be used for the research of neurodegenerative diseases, including Parkinson's disease .
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-
-
- HY-108637
-
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MDM-2/p53
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Cancer
|
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PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM. PhiKan 083 can be used for cancer research .
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-
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- HY-103382
-
|
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Fungal
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Cancer
|
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Arcyriaflavin A is an indolo[2,3-a]carbazole compound and also a cyclin D1/CDK4 inhibitor. Arcyriaflavin A exists in the marine ascidian Eudistoma sp. and the slime mold Arcyria denudata. Arcyriaflavin A is applicable to research related to colon cancer and lung cancer .
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-
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- HY-121368
-
|
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Parasite
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Infection
Inflammation/Immunology
Cancer
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Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.
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-
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- HY-W106456
-
-
-
- HY-135776
-
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o-BMVC
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G-quadruplex
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Cancer
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BMVC2 (o-BMVC) is a bisubstitute carbazole derivative of BMVC. BMVC2 is a G-quadruplex (G4) stabilizer .
|
-
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- HY-135775
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BMVC
1 Publications Verification
|
G-quadruplex
Telomerase
DNA/RNA Synthesis
|
Cancer
|
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BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor with an IC50 of ~0.2 μM. BMVC inhibits Taq DNA polymerase with an IC50 of ~2.5 μM. BMVC increases the melting temperature of G4 structure of telomere and accelerates telomere length shortening. Anticancer activities .
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-
-
- HY-W022224
-
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Endogenous Metabolite
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Others
|
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3,6-Diiodo-9H-carbazole is an organic compound that can be used for the design and synthesis of carbazole derivatives .
|
-
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- HY-N9488
-
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Girinimbin
|
Apoptosis
Bacterial
Parasite
|
Infection
Inflammation/Immunology
Cancer
|
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Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities .
|
-
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- HY-108510
-
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BW 234U dihydrochloride
|
Sigma Receptor
Dopamine Receptor
|
Neurological Disease
Cancer
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Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer .
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-
-
- HY-W047478
-
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NSC 10154
|
Fungal
Interleukin Related
|
Infection
Inflammation/Immunology
Cancer
|
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3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC50 of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases .
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-
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- HY-W106860
-
|
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Drug Intermediate
|
Cancer
|
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9H-Carbazole-3-carbaldehyde is an anticancer agent that can be isolated from the stems of Lansium parasiticum (Lour.) Skeels. 9H-Carbazole-3-carbaldehyde shows significant cytotoxic activity in a variety of tumor cell lines, especially against H1299 and SMMC-7721 lung cancer cells with IC50 values of 6.19-26.84 μg/mL .
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- HY-111523
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-
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- HY-148179
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-
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- HY-W279140S
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Isotope-Labeled Compounds
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Others
|
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Pirlindole-d4 (hydrochloride) is deuterium labeled 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride.
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- HY-W014334
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-
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- HY-117396
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Others
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Others
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Isomahanimbine is a natural carbazole alkaloid found in Murraya koenigii (L.) Spreng .
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-
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- HY-119983
-
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DBC
|
Environmental Pollutants
Cytochrome P450
|
Cancer
|
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7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .
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![7H-Dibenzo[c,g]carbazole](//file.medchemexpress.com/product_pic/hy-119983.gif)
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- HY-116933
-
|
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Topoisomerase
Bacterial
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Infection
Inflammation/Immunology
|
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Murrayanol is a natural carbazole alkaloid with a variety of biological activities. Murrayanol shows anti-inflammatory, topoisomerase I and topoisomerase II (Topoisomerase) inhibition activities. Murrayanol also as a mosquitocidal and antimicrobial .
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- HY-N16649
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|
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Others
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Neurological Disease
|
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Clausenalansine B (Compound 2) is a carbazole alkaloid found in the fruits of Clausena lansium. Clausenalansine B exhibits potent neuroprotective effects. Clausenalansine B prevents SH-SY5Y cells death from 6-OHDA (HY-B1081A) with an EC50 of 5.82 μM. Clausenalansine B can be used for the research of neurological disease, such as Parkinson’s disease .
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- HY-N3288
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Others
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Others
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Methylcarbazole-3-carboxylate is a carbazole alkaloid can be isolated from the peel of Clausena lansium (Lour.) Skeels .
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-
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- HY-N8361
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HIV
Apoptosis
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Infection
Cancer
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Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells .
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-
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- HY-108637A
-
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MDM-2/p53
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Cancer
|
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PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM , and a relative binding affinity (Kd) of 150 μM in Ln229 cells .
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-
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- HY-P0077
-
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Oxytocin Receptor
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Endocrinology
|
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Merotocin is a selective, short-acting peptidic oxytocin receptor agonist. Merotocin can be used to support lactation .
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- HY-U00323
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-
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- HY-W710314
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Bacterial
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Infection
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3,4-Dimethoxy-1,2-dimethyl-9H-carbazole is a carbazole alkaloid that can be used in the synthesis of baccamycin.
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-
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- HY-W090625S
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5H-[1]Benzofuro[3,2-c]carbazole-d10
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Isotope-Labeled Compounds
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Others
|
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5H-Benzofuro[3,2-c]carbazole-d10 is the deuterium labeled 5H-Benzofuro[3,2-c]carbazole (HY-W090625) .
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![5H-Benzofuro[3,2-c]carbazole-d10](//file.medchemexpress.com/product_pic/hy-w090625s.gif)
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- HY-W011565S1
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-
-
- HY-W011565S
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-
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- HY-N13828
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|
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Bacterial
Interleukin Related
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Infection
Inflammation/Immunology
|
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1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole (Compound 19) is a carbazole alkaloid that can be isolated from Murraya koenigii. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole exhibits anti-inflammatory and antimicrobial activities. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can inhibit the production of pro-inflammatory cytokines TNF-α and IL-6 . 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole has IC50 values of 10.9 μM and 95 μM for Bacillus cereus and Staphylococcus aureus, respectively. 1-Prenyl-2-methoxy-6-formyl-8-hydroxy-9H-carbazole can be used in the research of inflammatory and infectious diseases .
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- HY-W867679S
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-
![5,12-Dihydro-12-phenylindolo[3,2-a]carbazole-d16](//file.medchemexpress.com/product_pic/hy-w867679s.gif)
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- HY-W002468R
-
|
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Reference Standards
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1,2,3,9-Tetrahydro-9-methyl-4H-carbazole-4-one (Standard) is the analytical standard of 1,2,3,9-Tetrahydro-9-methyl-4H-carbazole-4-one. This product is intended for research and analytical applications.
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- HY-N3593
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1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde
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CDK
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Others
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Clausine Z (1,6-Dihydroxy-9H-carbazole-3-carboxaldehyde) is an alkaloid CDK5 inhibitor isolated from the plant from Momordica charantia .
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-
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- HY-W357781S
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Isotope-Labeled Compounds
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Others
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9,9'-(6-Chloro-1,3,5-triazine-2,4-diyl)bis(9H-carbazole)-d16 is the deuterium labeled 9,9'-(6-Chloro-1,3,5-triazine-2,4-diyl)bis(9H-carbazole).
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- HY-154363
-
|
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Nucleoside Antimetabolite/Analog
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Cancer
|
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3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-161910
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Anaplastic lymphoma kinase (ALK)
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Cancer
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SH-E4A-66 is a C 2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide). SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 μM) .
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- HY-N15266
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- HY-N15268
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SARS-CoV
Virus Protease
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Infection
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Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (M pro), which can be used in the research of anti-novel coronavirus drugs .
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- HY-146467
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Drug Derivative
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Cancer
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Anticancer agent 62 (compound 4c) is a potent anticancer agent. Anticancer agent 62 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC50 values of 0.019, 0.060 and 0.016 μM, respectively. Anticancer agent 62 shows effective tumor growth inhibition .
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- HY-N13286
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Bacterial
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Infection
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Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC50 values of 120.86 µg/mL and 97.74 µg/mL, respectively .
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- HY-P2331
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Antibiotic A 3802-IV-3; Gardimycin
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Antibiotic
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Infection
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Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
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- HY-179018
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Topoisomerase
Reactive Oxygen Species (ROS)
Apoptosis
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Cancer
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Topoisomerase II-IN-25 (Compound 6a) is a selective inhibitor of topoisomerase II and has no inhibitory activity on topoisomerase I. Topoisomerase II-IN-25 exhibits significant anti-PC-3 cell activity. Topoisomerase II-IN-25 significantly increases intracellular ROS levels, inducing oxidative stress. Topoisomerase II-IN-25 causes depolarization of mitochondrial membrane potential and promotes cell apoptosis. Topoisomerase II-IN-25 blocks PC-3 cells in the G2/M phase. Topoisomerase II-IN-25 can be used for the study of prostate cancer .
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- HY-146466
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Others
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Cancer
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Anticancer agent 61 (compound 3v) is an orally active and potent anticancer agent. Anticancer agent 61 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC50 values of 1.12, 1.97 and 1.08 μM, respectively. Anticancer agent 61 shows effective tumor growth inhibition .
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- HY-151468
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Fluorescent Dye
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Others
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AIECbz-LD-C7 is an aggregation-induced emission (AIE) probe based on the conjugation of quinoline-malononitrile (QM) and carbazole. AIECbz-LD-C7 has excellent LD-specificity. AIECbz-LD-C7 can be used for tracking the dynamic changes of LDs and studying the association between LDs and lysosome/endoplasmic reticulum (ER) .
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- HY-163775
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MyD88
NF-κB
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Inflammation/Immunology
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Anti-inflammatory agent 88 (compound 6) is a carbazole derivative with anti-inflammatory activity found in marine Streptomyces. It exerts its anti-inflammatory effect by inhibiting pro-inflammatory factors and enhancing the expression of anti-inflammatory factors in the Myd88/Nf-κB pathway. Anti-inflammatory agent 88 can be used for the development of anti-inflammatory drugs .
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- HY-23278
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3,6-Diphenyl-9H-carbazole
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MOFs
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Others
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3,6-Biphenyl-9H-carbazole (3,6-Diphenyl-9H-Carbazole) is a metal-organic framework (MOF).
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- HY-W103764S1
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-
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- HY-W338631
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9H-carbazole-3,6-dicarboxylic acid, 3,6-dimethyl ester
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MOFs
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Others
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Dimethyl 9H-carbazole-3,6-dicarboxylate (9H-Carbazole-3,6-dicarboxylic acid, 3,6-dimethyl ester) is a metal-organic framework (MOF).
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- HY-W109418S
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- HY-W106860R
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Others
Reference Standards
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Cancer
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9H-Carbazole-3-carbaldehyde (Standard) is the analytical standard of 9H-Carbazole-3-carbaldehyde (HY-W106860). This product is intended for research and analytical applications. 9H-Carbazole-3-carbaldehyde is an anticancer agent that can be isolated from the stems of Lansium parasiticum (Lour.) Skeels. 9H-Carbazole-3-carbaldehyde shows significant cytotoxic activity in a variety of tumor cell lines, especially against H1299 and SMMC-7721 lung cancer cells with IC50 values of 6.19-26.84 μg/mL .
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- HY-23805S
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- HY-W392536
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MOFs
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Others
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9H-carbazole-2,7-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W112202
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MOFs
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Others
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9H-Carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W112515
-
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MOFs
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Others
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3,6-Di(4-pyridylethynyl)carbazole is a metal-organic framework (MOF).
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- HY-166928S
-
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- HY-W456436
-
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MOFs
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Others
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9-(Pyridin-4-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W243923
-
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MOFs
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Others
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9-Phenyl-9H-carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W550270
-
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MOFs
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Others
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9-Ethyl-9h-carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W112131
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3,6-Bis[N,N-bis(4-methoxyphenyl)amino]-9H-carbazole
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MOFs
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Others
|
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N,N,N',N'-Tetrakis(4-methoxyphenyl)-9H-carbazole-3,6-diamine(3,6-Bis[N,N-bis(4-methoxyphenyl)amino]-9H-carbazole) is a metal-organic framework (MOF).
|
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- HY-W441633S
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-
![12H-Benzo[4,5]thieno[2,3-a]carbazole-d10](//file.medchemexpress.com/product_pic/hy-w441633s.gif)
- HY-W112432
-
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MOFs
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Others
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4,4'-(9H-carbazole-3,6-diyl)dibenzoic acid is a metal-organic framework (MOF).
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- HY-W1049948
-
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MOFs
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Others
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5,5'-(9H-carbazole-3,6-diyl)diisophthalic acid is a metal-organic framework (MOF).
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- HY-W112513
-
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MOFs
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Others
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3,6-Di(pyridin-4-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W037730
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3,6-Dinitrocarbazole
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MOFs
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Others
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3,6-Dinitro-9H-carbazole(3,6-Dinitrocarbazole) is a metal-organic framework (MOF).
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- HY-W543642
-
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MOFs
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Others
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2,7-Di(pyridin-4-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W112213
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MOFs
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Others
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9-(4-Carboxyphenyl)-9H-carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W543665
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MOFs
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Others
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Dimethyl4,4'-(9H-carbazole-3,6-diyl)dibenzoate is a metal-organic framework (MOF).
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- HY-W249377
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MOFs
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Others
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9-(3,5-Dicarboxybenzyl)-9H-carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W248989
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MOFs
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Others
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4,4',4''-(9H-Carbazole-3,6,9-triyl)tribenzoic acid is a metal-organic framework (MOF).
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- HY-W1049886
-
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MOFs
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Others
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5,5',5''-(9H-Carbazole-3,6,9-triyl)triisophthalic acid is a metal-organic framework (MOF).
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- HY-W1049881
-
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MOFs
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Others
|
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9-(Pyridin-4-yl)-9H-carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
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- HY-W543663
-
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MOFs
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Others
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3,6-Di-tert-butyl-9-(4-vinylphenyl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W112517
-
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MOFs
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Others
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3,6-Di(1H-imidazol-1-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W543656
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MOFs
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Others
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2,7-Di(1H-imidazol-1-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W112205
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MOFs
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Others
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9-Ethyl-3,6-di(pyridin-4-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W093235
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MOFs
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Others
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4,4',4'',4'''-(9H-Carbazole-1,3,6,8-tetrayl)tetrabenzoic acid is a metal-organic framework (MOF).
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- HY-W543751
-
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MOFs
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Others
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9,9'-(1,4-Phenylenebis(methylene))bis(9H-carbazole-3,6-dicarboxylicacid) is a metal-organic framework (MOF).
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- HY-W588992
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MOFs
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Others
|
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(9-(4-Fluorophenyl)-9H-carbazole-3,6-diyl)bis((4-fluorophenyl)methanone) is a metal-organic framework (MOF).
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- HY-W456449
-
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MOFs
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Others
|
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9-Ethyl-2,7-di(1H-imidazol-1-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W112206
-
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MOFs
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Others
|
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9-Ethyl-3,6-di(1H-pyrazol-1-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W112207
-
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MOFs
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Others
|
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9-Ethyl-3,6-di(1H-imidazol-1-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W1049928
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MOFs
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Others
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9-(4'-Carboxy-[1,1'-biphenyl]-4-yl)-9H-carbazole-3,6-dicarboxylic acid is a metal-organic framework (MOF).
|
-
![9-(4'-Carboxy-[1,1'-biphenyl]-4-yl)-9H-carbazole-3,6-dicarboxylic acid](//file.medchemexpress.com/product_pic/hy-w1049928.gif)
- HY-W112217
-
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MOFs
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Others
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6,6',6",6"'-(9H-Carbazole-1,3,6,8-tetrayl)tetrakis(2-naphthoic acid) is a metal-organic framework (MOF).
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- HY-W647293
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Drug Derivative
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Others
|
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3-Methyl-9H-carbazol-2-ol (compound 7) is a carbazole alkaloid that can be found in the twigs and leaves of Glycosmis montana Pierre (Rutaceae) .
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- HY-W112786
-
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MOFs
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Others
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1,3,6,8-Tetra(1H-imidazol-1-yl)-9-methyl-9H-carbazole is a metal-organic framework (MOF).
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- HY-W1049792
-
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MOFs
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Others
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3,6-Di(Pyridin-4-yl)-9-(4-(pyridin-4-yl)phenyl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W456466
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MOFs
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Others
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5,10,15-Trimethyl-10,15-dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole is a metal-organic framework (MOF).
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![5,10,15-Trimethyl-10,15-dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole](//file.medchemexpress.com/product_pic/hy-w456466.gif)
- HY-W249380
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MOFs
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Others
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9-Butyl-2,7-di(1H-1,2,4-triazol-1-yl)-9H-carbazole is a metal-organic framework (MOF).
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- HY-W456518
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MOFs
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Others
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4,4'-(9-(4'-Carboxy-[1,1'-biphenyl]-4-yl)-9H-carbazole-3,6-diyl)dibenzoic acid is a metal-organic framework (MOF).
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![4,4'-(9-(4'-Carboxy-[1,1'-biphenyl]-4-yl)-9H-carbazole-3,6-diyl)dibenzoic acid](//file.medchemexpress.com/product_pic/hy-w456518.gif)
- HY-N16772
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- HY-W1006753
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- HY-W243789S
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- HY-34549S
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- HY-W423338S1
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![5-([1,1'-Biphenyl]-4-yl)-5,8-dihydroindolo[2,3-c]carbazole-d20](//file.medchemexpress.com/product_pic/hy-w423338s1.gif)
- HY-33672R
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9-Phenyl-9H-carbazole (Standard); N-Phenylcarbazole (Standard); N-PHENYLcarbazole HYDROCHLORIDE (Standard)
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Reference Standards
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9-Phenylcarbazole (Standard) is the analytical standard of 9-Phenylcarbazole. This product is intended for research and analytical applications.
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- HY-N19719
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Drug Derivative
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Inflammation/Immunology
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Bispyrayafoline is a pyrrolidone and antioxidant with an IC50 value of 13.85 μM against DPPH. Bispyrayafoline can be found in the leaves of Murraya koenigii (Linn.) Spreng. Bispyrayafoline's antioxidant activity is concentration-dependent but time-independent. Bispyrayafoline can be utilized in studies concerning oxidative damage .
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- HY-108637R
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Reference Standards
MDM-2/p53
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Cancer
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PhiKan 083 (Standard) is the analytical standard of PhiKan 083 (HY-108637). This product is intended for research and analytical applications. PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM. PhiKan 083 can be used for cancer research .
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- HY-N16748
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Others
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Cardiovascular Disease
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Heptazoline is a carbazole alkaloid that can be isolated from the stem bark of Clausena excavata. Heptazoline exhibits significant antiplatelet aggregation activity (inhibiting platelet aggregation induced by arachidonic acid, collagen, etc.) and certain vasodilatory activity (inhibiting norepinephrine-induced contraction of rat aorta). Heptazoline can be used in antithrombotic research in the cardiovascular field .
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- HY-N3993
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- HY-P1726
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Melanocortin Receptor
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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MSG606 is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 can delay pain hypersensitivity and reduce cholesterol levels. MSG606 can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .
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- HY-P1726A
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Melanocortin Receptor
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .
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- HY-108510R
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BW 234U dihydrochloride (Standard)
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Reference Standards
Sigma Receptor
Dopamine Receptor
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Neurological Disease
Cancer
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Rimcazole dihydrochloride (Standard) is the analytical standard of Rimcazole (dihydrochloride) (HY-108510). This product is intended for research and analytical applications. Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer .
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- HY-N16714
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Others
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Cancer
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Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC50 = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC50 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .
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- HY-179523
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Drug Derivative
NAMPT
Microtubule/Tubulin
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Neurological Disease
Cancer
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Carba1 is a bifunctional Carbazole (HY-D0204) derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances NAD biosynthesis. Carba1 binds to colchicine site of tubulin, enhancing the anti-tumor effect of various chemotherapy drugs, such as Paclitaxel (HY-B0015). Carba1 exerts neuroprotective effect and can regulate cell energy metabolism. Carba1 can be used for the researches of cancer and chemotherapy-induced peripheral neuropathy (CIPN) .
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- HY-W047478R
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NSC 10154 (Standard)
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Reference Standards
Interleukin Related
Fungal
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Infection
Inflammation/Immunology
Cancer
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3-Methylcarbazole (NSC 10154) Standard is the analytical standard of 3-Methylcarbazole (HY-W047478). This product is intended for research and analytical applications. 3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC50 of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases.
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- HY-179670
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Bacterial
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Infection
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Antibacterial agent 304 (Compound 3a) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 8 μg/mL against S. aureus and P. aeruginosa. This antibacterial agent has a bactericidal effect and can disrupt the integrity of the cell wall. Antibacterial agent 304 has the potential to be a sustainable organic photocatalyst .
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- HY-183570
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Photosensitizer
Reactive Oxygen Species (ROS)
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Cancer
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Antitumor photosensitizer-11 is a type-I carbazole/benzindolium photosensitizer with antitumor activity. Antitumor photosensitizer-11 induces ROS generation via a type-I pathway, forming superoxide anions and hydroxyl radicals. Antitumor photosensitizer-11 triggers immunogenic cell death in cancer cells via enhanced oxidative stress. Antitumor photosensitizer-11 exhibits antiproliferative activity in normoxic and hypoxic environments, inhibits breast cancer tumor growth in vivo, and promotes dendritic cell maturation and T cell infiltration. Antitumor photosensitizer-11 can be used for the research of cancer, such as breast cancer .
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- HY-P0041
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- HY-P0041A
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- HY-180452
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Paraptosis
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Infection
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HAT-IN-10 (Compound 12a) is an anti-human African trypanosomiasis (HAT) agent, with an EC50 value of 0.23 μM for T. brucei. HAT-IN-10 can be used for research on HAT .
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- HY-W100287
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NF-κB
p38 MAPK
Interleukin Related
IKK
JNK
β-catenin
Wnt
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Neurological Disease
Inflammation/Immunology
Cancer
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Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .
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- HY-15334
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VEGFR
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Cancer
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CEP-5214, derived from a new indenopyrrolocarbazole template, is a potent inhibitor of vascular endothelial growth factor R2 (VEGF-R2) tyrosine kinase. Structurally, it features optimal substitutions at positions 9 (ethoxymethyl) and 12 (hydroxypropyl) on the indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-one scaffold, leading to high potency against VEGF-R2 (IC50 8 nM). Compound 21 (CEP-5214) exhibits low-nanomolar inhibition of human VEGF-R tyrosine kinases (IC50 4 nM for VEGF-R2/KDR), with good selectivity over other kinases. The compound demonstrated significant cellular and in vivo antitumor activity across various models and advanced into phase I clinical trials as a water-soluble prodrug (CEP-7055) to enhance oral bioavailability .
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- HY-W100287R
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NF-κB
Reference Standards
p38 MAPK
Interleukin Related
IKK
JNK
β-catenin
Wnt
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Neurological Disease
Inflammation/Immunology
Cancer
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Murrayafoline A (Standard) is the analytical standard of Murrayafoline A (HY-W100287). This product is intended for research and analytical applications. Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/β-catenin pathway by promoting the degradation of intracellular β-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS (HY-D1056)-induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer .
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| Cat. No. |
Product Name |
Type |
| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P1726
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Melanocortin Receptor
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
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MSG606 is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 can delay pain hypersensitivity and reduce cholesterol levels. MSG606 can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .
|
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- HY-P0077
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Oxytocin Receptor
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Endocrinology
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Merotocin is a selective, short-acting peptidic oxytocin receptor agonist. Merotocin can be used to support lactation .
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- HY-P1726A
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Melanocortin Receptor
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
MSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH) .
|
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- HY-P0041A
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-
- HY-P2331
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Antibiotic A 3802-IV-3; Gardimycin
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Antibiotic
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Infection
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|
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
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- HY-P10014
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- HY-P0041
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W279140S
-
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|
|
Pirlindole-d4 (hydrochloride) is deuterium labeled 8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazole hydrochloride.
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- HY-W090625S
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5H-Benzofuro[3,2-c]carbazole-d10 is the deuterium labeled 5H-Benzofuro[3,2-c]carbazole (HY-W090625) .
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- HY-W011565S1
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3,6-Di-tert-butyl-9H-carbazole-d25 is a deuterium labeled 3,6-Di-tert-butyl-9H-carbazole.
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-
- HY-W011565S
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3,6-Di-tert-butyl-9H-carbazole-d6 is the deuterium labeled 3,6-Di-tert-butyl-9H-carbazole.
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- HY-W867679S
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5,12-Dihydro-12-phenylindolo[3,2-a]carbazole-d16 is a deuterium labeled compound.
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-
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- HY-W357781S
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9,9'-(6-Chloro-1,3,5-triazine-2,4-diyl)bis(9H-carbazole)-d16 is the deuterium labeled 9,9'-(6-Chloro-1,3,5-triazine-2,4-diyl)bis(9H-carbazole).
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- HY-W103764S1
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3-Phenyl-9H-carbazole-d12 is the deuterium labeled 3-Phenyl-9H-carbazole.
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-
-
- HY-W109418S
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2,9′-Bi-9H-carbazole-d15 is the deuterium labeled 2,9′-Bi-9H-carbazole.
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-
-
- HY-23805S
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3,6-Dichloro-9H-carbazole- 13C12 is 13C labeled 3,6-Dichloro-9H-carbazole .
|
-
-
- HY-166928S
-
|
|
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1,3,6,8-Tetrachloro-9H-carbazole- 13C12 is 13C labeled 1,3,6,8-Tetrachloro-9H-carbazole .
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- HY-W441633S
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|
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12H-Benzo[4,5]thieno[2,3-a]carbazole-d10 is the deuterium labeled 12H-Benzo[4,5]thieno[2,3-a]carbazole.
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- HY-W243789S
-
-
-
- HY-34549S
-
-
-
- HY-W423338S1
-
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-154363
-
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Phosphoramidites
|
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3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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