1020407-90-2
Chemical Structure
Chemerin15
- CAS No.: 1020407-90-2
- Formula:C75H100N18O22
- Molecular Weight:1605.70
InChIKey: QTFBQQVMWXNUGD-HRKVGLAYSA-N
SMILES: O=C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC=N2)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N5[C@@H](CCC5)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury[1][2][3].
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Chemerin15 | 99.65% | Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury. | ||||||||||||||||||||
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- [1]. Cash JL, et al. Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner. J Immunol. 2010;184(9):5315-5324. [Content Brief]
- [2]. Yang Y, et al. Chemerin 15 enhances microglial phagocytosis to attenuate cerebral ischemia-reperfusion injury through the ChemR23/p38 MAPK pathway. iScience. 2025;28(9):113396. Published 2025 Aug 19. [Content Brief]
- [3]. Cash JL, et al. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23. EMBO Rep. 2013;14(11):999-1007. [Content Brief]
Keywords
