1033699-22-7
1033699-22-7
Chemical Structure
Maraviroc-d6
- CAS No.: 1033699-22-7
- Formula:C29H35D6F2N5O
- Molecular Weight:519.70
IUPAC Name: 4,4-difluoro-N-((S)-3-((1R,3R,5S)-3-(3-methyl-5-(propan-2-yl-1,1,1,3,3,3-d6)-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide
InChIKey: GSNHKUDZZFZSJB-RECUSMSCSA-N
SMILES: C(C[C@H](NC(=O)C1CCC(F)(F)CC1)C2=CC=CC=C2)N3[C@@H]4C[C@@H](C[C@H]3CC4)N5C(C(C([2H])([2H])[2H])C([2H])([2H])[2H])=NN=C5C
Biological Activity: Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV[1][2].
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Maraviroc-d6 | Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV. | |||||||||||||||||||||
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Maraviroc (Standard) | ≥98% | Maraviroc (Standard) is the analytical standard of Maraviroc. This product is intended for research and analytical applications. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV. | ||||||||||||||||||||
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Maraviroc | 99.98% | Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Dorr P, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov;49(11):472 [Content Brief]
