103878-83-7
Chemical Structure
Lazabemide hydrochloride
Synonym(s): Ro 19-6327 hydrochloride
- CAS No.: 103878-83-7
- Formula:C8H11Cl2N3O
- Molecular Weight:236.10
IUPAC Name: N-(2-aminoethyl)-5-chloropicolinamide hydrochloride
InChIKey: JMFKTFLARGGXCC-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(Cl)C=C1)NCCN.[H]Cl
Biological Activity: Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease[1].
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Lazabemide hydrochloride | 95.0% | Lazabemide hydrochloride (Ro 19-6327 hydrochloride) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease. | ||||||||||||||||||||
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Keywords
