103878-84-8
Chemical Structure
Lazabemide
Synonym(s): Ro 19-6327
- CAS No.: 103878-84-8
- Formula:C8H10ClN3O
- Molecular Weight:199.64
IUPAC Name: N-(2-aminoethyl)-5-chloropicolinamide
InChIKey: JZXRLKWWVNUZRB-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C(NCCN)=O)N=C1
Biological Activity: Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease[1].
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Lazabemide | 99.95% | Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM). Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease. | ||||||||||||||||||||
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Keywords
