10391-09-0
Chemical Structure
Nodosin
- CAS No.: 10391-09-0
- Formula:C20H26O6
- Molecular Weight:362.42
IUPAC Name: (3R,3aR,6aS,8aS,11S,13R,13aS,13bS)-3,13-dihydroxy-4,4-dimethyl-10-methylenedecahydro-1H,8H-8a,11-methanocyclohepta[c]furo[3,4-e]chromene-8,9(10H)-dione
InChIKey: WZYJEEIAFBHYJS-SONIPUFESA-N
SMILES: O[C@H]1[C@@]([C@]2(C(C3=C)=O)C[C@H]3C1)([H])[C@@]([C@@](CC4)([H])OC2=O)(CO5)[C@](C4(C)C)([H])[C@@H]5O
Biological Activity: Nodosin is an orally active diterpenoid compound that can be isolated from Isodon serra. Nodosin can inhibit the proliferation and induce cell cycle arrest and apoptosis of tumor cells. Nodosin can also inhibit oxidative stress, inflammatory responses, and ferroptosis. Nodosin has anti-inflammatory and anti-tumor activities[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nodosin | 98.61% | Nodosin is an orally active diterpenoid compound that can be isolated from Isodon serra. Nodosin can inhibit the proliferation and induce cell cycle arrest and apoptosis of tumor cells. Nodosin can also inhibit oxidative stress, inflammatory responses, and ferroptosis. Nodosin has anti-inflammatory and anti-tumor activities. | ||||||||||||||||||||
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- [1]. Bae ES, et al. Anti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells. Biomol Ther (Seoul). 2020 Sep 1;28(5):465-472. [Content Brief]
- [2]. Su C, et al. Protective effects of nodosin against lipopolysaccharide-induced acute kidney injury through regulation of oxidative stress, inflammation, and ferroptosis in rats. Naunyn Schmiedebergs Arch Pharmacol. 2024 Oct;397(10):8009-8022 [Content Brief]
- [3]. Zhou X, et al. Effect of nodosin on accelerating hepatocyte regeneration after partial liver transplantation in rats. Organ Transplantation, 2016: 132-138.
Keywords
