105128-93-6
105128-93-6
Chemical Structure
HO 221
- CAS No.: 105128-93-6
- Formula:C18H11BrClN5O5
- Molecular Weight:492.67
IUPAC Name: N-((4-((5-bromopyrimidin-2-yl)oxy)-3-chlorophenyl)carbamoyl)-2-nitrobenzamide
InChIKey: WKXWMGOTZJGIIK-UHFFFAOYSA-N
SMILES: ClC1=C(OC2=NC=C(Br)C=N2)C=CC(NC(NC(C3=C(C=CC=C3)[N+]([O-])=O)=O)=O)=C1
Biological Activity: HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia[1].
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HO 221 | HO 221 is an orally active benzoylphenylurea derivative with antitumor activity. HO 221 can inhibit the activity of mammalian DNA polymerase alpha. HO 221 can induce G1 phase arrest. HO 221 can be used for the research of cancer, such as leukemia. | |||||||||||||||||||||
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References
Keywords
