105462-23-5
Chemical Structure
NE58018
- CAS No.: 105462-23-5
- Formula:C7H11NO7P2
- Molecular Weight:283.11
IUPAC Name: (1-hydroxy-2-(pyridin-2-yl)ethane-1,1-diyl)bis(phosphonic acid)
InChIKey: XXNASZAYANFLID-UHFFFAOYSA-N
SMILES: OC([P](O)(O)=O)([P](O)(O)=O)CC1=CC=CC=N1
Biological Activity: NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme[1].
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NE58018 | NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme. | |||||||||||||||||||||
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Keywords
