1059734-66-5
1059734-66-5
Chemical Structure
BMS-833923
Synonym(s): XL-139
- CAS No.: 1059734-66-5
- Formula:C30H27N5O
- Molecular Weight:473.57
IUPAC Name: N-(2-methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide
InChIKey: KLRRGBHZCJLIEL-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2
Biological Activity: BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC50 of 21 nM[1].
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BMS-833923 | 99.82% | BMS-833923 (XL-139) is an orally biocompatible Smoothened (Smo) inhibitor with anti-tumor activity. It can inhibit the binding of BODIPY cyclopamine to SMO in a dose-dependent manner with an IC50 of 21 nM. | ||||||||||||||||||||
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References
Keywords
