107021-36-3
Chemical Structure
Prazobind
Synonym(s): SZL 49
- CAS No.: 107021-36-3
- Formula:C23H27N5O3
- Molecular Weight:421.49
IUPAC Name: (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(bicyclo[2.2.2]octa-2,5-dien-2-yl)methanone
InChIKey: MXXRJJCMLRPJOF-UHFFFAOYSA-N
SMILES: NC1=NC(N(CC2)CCN2C(C3=CC4CCC3C=C4)=O)=NC(C=C5OC)=C1C=C5OC
Biological Activity: Prazobind (SZL 49), a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure[1][2][3][4].
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Prazobind | 96.20% | Prazobind (SZL 49), a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure. | ||||||||||||||||||||
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Prazobind-d8 | Prazobind-d8 (SZL 49-d8) is the deuterium labeled Prazobind (HY-118335). Prazobind, a prazosin analog, is an irreversible α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind partially inhibits the contractions of circular muscles, longitudinal muscles and smooth muscles of the spleen. Prazobind can be used for the study of blood pressure. | |||||||||||||||||||||
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- [1]. Mante S, et al. The alkylating prazosin analog SZL 49 inactivates both alpha 1A- and alpha 1B-adrenoceptors. Eur J Pharmacol. 1991;208(2):113-117. [Content Brief]
- [2]. Tabrizchi R, et al. The effects of losartan and captopril on vasopressor actions of cirazoline in the absence and presence of SZL-49 and nifedipine. J Cardiovasc Pharmacol. 1995 Jul;26(1):137-44. [Content Brief]
- [3]. Amobi NI, et al. Discrimination by SZL49 between contractions evoked by noradrenaline in longitudinal and circular muscle of human vas deferens. Br J Pharmacol. 2002 May;136(1):127-35. [Content Brief]
- [4]. Eltze M. Functional evidence for an alpha 1B-adrenoceptor mediating contraction of the mouse spleen. Eur J Pharmacol. 1996 Sep 12;311(2-3):187-98. [Content Brief]
Keywords
