1087624-28-9
1087624-28-9
Chemical Structure
KLK5/14-IN-1
- CAS No.: 1087624-28-9
- Formula:C18H17NO4S
- Molecular Weight:343.40
IUPAC Name: 6-ethoxy-7-methoxy-2-(2-(methylthio)phenyl)-4H-benzo[d][1,3]oxazin-4-one
InChIKey: JTQBMTFVGGUDPN-UHFFFAOYSA-N
SMILES: O=C1OC(=NC2=CC(OC)=C(OCC)C=C12)C=3C=CC=CC3SC
Biological Activity: KLK5/14-IN-1 is a selective human skin kallikrein inhibitor with IC50 values of 0.048 μM, 0.2 μM, and 0.1 μM for KLK7, KLK5, and KLK14, respectively. KLK5/14-IN-1 shows no or only low inhibitory activity against Cathepsin G, Chymotrypsin, Trypsin, and Thrombin. KLK5/14-IN-1 can be used in research related to Netherton syndrome[1].
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KLK5/14-IN-1 | KLK5/14-IN-1 is a selective human skin kallikrein inhibitor with IC50 values of 0.048 μM, 0.2 μM, and 0.1 μM for KLK7, KLK5, and KLK14, respectively. KLK5/14-IN-1 shows no or only low inhibitory activity against Cathepsin G, Chymotrypsin, Trypsin, and Thrombin. KLK5/14-IN-1 can be used in research related to Netherton syndrome. | |||||||||||||||||||||
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