1093380-13-2
Chemical Structure
Olanzapine-d8
Synonym(s): LY170053-d8
- CAS No.: 1093380-13-2
- Formula:C17H12D8N4S
- Molecular Weight:320.48
IUPAC Name: 2-methyl-4-(4-methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)-10H-benzo[b]thieno[2,3-e][1,4]diazepine
InChIKey: KVWDHTXUZHCGIO-UFBJYANTSA-N
SMILES: CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C4([2H])[2H])C
Biological Activity: Olanzapine-d8 is a deuterated labeled Olanzapine[1]. Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Olanzapine-d8 | Olanzapine-d8 is a deuterated labeled Olanzapine. Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Olanzapine (Standard) | 99.98% | Olanzapine (Standard) is the analytical standard of Olanzapine. This product is intended for research and analytical applications. Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Olanzapine-d4 | Olanzapine-d4 (LY170053-d4) is deuterium-labeled Olanzapine (HY-14541). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Olanzapine-d3 | 98.57% | Olanzapine-d3 (LY170053-d3) is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Olanzapine-d15 | Olanzapine-d15 (LY170053-d15) is the deuterium labeled Olanzapine (HY-14541). Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki = 7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki = 11 to 31 nM), muscarinic M1-5 (Ki = 1.9-25 nM), and adrenergic α1 receptor (Ki = 19 nM). Olanzapine is an atypical antipsychotic. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Olanzapine | 99.96% | Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78. [Content Brief]
- [3]. APPROVED AGREED-UPON LABELING.
