1093412-18-0
1093412-18-0
Chemical Structure
Roflupram
- CAS No.: 1093412-18-0
- Formula:C16H20F2O4
- Molecular Weight:314.32
IUPAC Name: 1-(4-(difluoromethoxy)-3-((tetrahydrofuran-3-yl)oxy)phenyl)-3-methylbutan-1-one
InChIKey: IXURVUHDDXFYDR-UHFFFAOYSA-N
SMILES: CC(CC(C1=CC=C(C(OC2COCC2)=C1)OC(F)F)=O)C
Biological Activity: Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Roflupram | 99.45% | Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors. | ||||||||||||||||||||
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References
- [1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [Content Brief]
- [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392. [Content Brief]
Keywords
