109719-94-0
109719-94-0
Chemical Structure
1,2,3,4,7,8,9-Heptachloro-dibenzofuran-13C12
- CAS No.: 109719-94-0
- Formula:13C12HCl7O
- Molecular Weight:421.22
IUPAC Name: 1,2,3,4,7,8,9-heptachlorodibenzo[b,d]furan-1,2,3,4,4a,5a,6,7,8,9,9a,9b-13C12
InChIKey: VEZCTZWLJYWARH-WCGVKTIYSA-N
SMILES: Cl[13C]1=[13C](Cl)[13C](Cl)=[13C](Cl)[13C]2=[13C]1[13C]3=[13C](Cl)[13C](Cl)=[13C](Cl)[13CH]=[13C]3O2
Biological Activity: 1, 2, 3, 4, 7, 8, 9-Heptachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8,9-Heptachlorodibenzo[b,d]furan[1].
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1,2,3,4,7,8,9-Heptachloro-dibenzofuran-13C12 | 1, 2, 3, 4, 7, 8, 9-Heptachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8,9-Heptachlorodibenzo[b,d]furan. | |||||||||||||||||||||
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1,2,3,4,7,8,9-Heptachlorodibenzofuran | 1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a compound that induces the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also promoting the expression of the aryl hydrocarbon receptor repressor (AhRR). 1,2,3,4,7,8,9-Heptachlorodibenzofuran can increase ethoxyresorufin-O-deethylase (EROD) activity in isolated human peripheral blood lymphocytes in a concentration-dependent manner, which serves as a marker of CYP1A1 activity. Furthermore, 1,2,3,4,7,8,9-Heptachlorodibenzofuran exhibits immunosuppressive effects by reducing the number of splenic plaque-forming cells in mice and increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes of mice injected with sheep red blood cells. 1,2,3,4,7,8,9-Heptachlorodibenzofuran can be used in research in the fields of immunology, metabolic diseases, and environmental toxicology. | |||||||||||||||||||||
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