112856-44-7
Chemical Structure
Losigamone
Synonym(s): AO-33; (±)-Losigamone; LSG
- CAS No.: 112856-44-7
- Formula:C12H11ClO4
- Molecular Weight:254.67
IUPAC Name: (S)-5-((R)-(2-chlorophenyl)(hydroxy)methyl)-4-methoxyfuran-2(5H)-one
InChIKey: ICDNYWJQGWNLFP-VXGBXAGGSA-N
SMILES: O[C@H](C1=C(C=CC=C1)Cl)[C@@]2([H])C(OC)=CC(O2)=O
Biological Activity: Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research[1][2].
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Losigamone | 99.94% | Losigamone (AO-33) is an orally active antiepileptic compound. Losigamone blocks sodium channel. Losigamone stimulates the neuronal chloride channel and enhance chloride influx. Losigamone potentiates GABA-mediated responses and reduces epileptiform activity induced by chloride channel antagonists. Losigamone can be used for epilepsy research. | ||||||||||||||||||||
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Keywords
