113963-68-1
113963-68-1
Chemical Structure
Bisindolylmaleimide V
Synonym(s): BIM V
- CAS. Nr.: 113963-68-1
- Formula:C21H15N3O2
- Molecular Weight:341.36
IUPAC Name: 3,4-di(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione
InChIKey: SWAWYMIKGOHZMR-UHFFFAOYSA-N
SMILES: O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)N(C)C3=O
Biological Activity: Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Bisindolylmaleimide V | 97.75% | Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360(2-3):281-4. [Content Brief]
- [2]. Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519(1-3):135-40. [Content Brief]
Keywords
