1147090-70-7
1147090-70-7
Chemical Structure
Camptothecin-20(S)-O-propionate hydrate
Synonym(s): Camptothecin-20-O-propionate hydrate
- CAS No.: 1147090-70-7
- Formula:C23H26N2O8
- Molecular Weight:458.46
IUPAC Name: (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl propionate trihydrate
InChIKey: IYMREUZGKUWKHF-AQUVTFJZSA-N
SMILES: O=C1[C@](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O.O.O.O
Biological Activity: Camptothecin-20(S)-O-propionate (Camptothecin-20-O-propionate) hydrate, the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate hydrate is a topoisomerase-Ι inhibitor[1][2].
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Camptothecin-20(S)-O-propionate hydrate | Camptothecin-20(S)-O-propionate (Camptothecin-20-O-propionate) hydrate, the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate hydrate is a topoisomerase-Ι inhibitor. | |||||||||||||||||||||
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References
- [1]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206. [Content Brief]
- [2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. [Content Brief]
