1189994-89-5
Chemical Structure
Valproic acid-d7 sodium
Synonym(s): Sodium Valproate-d7; VPA-d7 sodium; 2-Propylpentanoic acid-d7 sodium
- CAS No.: 1189994-89-5
- Formula:C8H8D7NaO3
- Molecular Weight:189.24
IUPAC Name: sodium 2-(3-hydroxypropyl)pentanoate-3,3,4,4,5,5,5-d7
InChIKey: CSZWWXWOLIYBAB-MDVNJVHASA-M
SMILES: OCCCC(C(O[Na])=O)C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
Biological Activity: Valproic acid-d7 (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
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Valproic acid-d7 sodium | Valproic acid-d7 (sodium) is the deuterium labeled Valproic acid (sodium salt). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium salt activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. [Content Brief]
Keywords
