1190196-76-9
Chemical Structure
PMPMEase-IN-1
- CAS No.: 1190196-76-9
- Formula:C12H21FO2S2
- Molecular Weight:280.42
IUPAC Name: (E)-2-((3,7-dimethylocta-2,6-dien-1-yl)thio)ethane-1-sulfonyl fluoride
InChIKey: TZWRSKIJUFQCKJ-KPKJPENVSA-N
SMILES: O=S(CCSC/C=C(C)/CC/C=C(C)\C)(F)=O
Biological Activity: PMPMEase-IN-1 is an allylated methylated protein methylesterase inhibitor with the property of inhibiting PMPMEase activity. PMPMEase-IN-1 may provide a useful strategy for cancer inhibition by enhancing its affinity for polyisoprenyl derivatives. PMPMEase-IN-1 showed the potential to have an effective concentration (EC50) value in causing degeneration of human neuroblastoma SH-SY5Y cells. Specific inhibition of PMPMEase-IN-1 may help regulate the metabolism of polyisoprenyl proteins and thus maintain normal cell survival. Further development and application of PMPMEase-IN-1 may open up new avenues for inhibiting degenerative diseases and cancer[1].
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PMPMEase-IN-1 | PMPMEase-IN-1 is an allylated methylated protein methylesterase inhibitor with the property of inhibiting PMPMEase activity. PMPMEase-IN-1 may provide a useful strategy for cancer inhibition by enhancing its affinity for polyisoprenyl derivatives. PMPMEase-IN-1 showed the potential to have an effective concentration (EC50) value in causing degeneration of human neuroblastoma SH-SY5Y cells. Specific inhibition of PMPMEase-IN-1 may help regulate the metabolism of polyisoprenyl proteins and thus maintain normal cell survival. Further development and application of PMPMEase-IN-1 may open up new avenues for inhibiting degenerative diseases and cancer. | |||||||||||||||||||||
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Keywords
