1191911-27-9
1191911-27-9
Chemical Structure
CZC-54252
- CAS No.: 1191911-27-9
- Formula:C22H25ClN6O4S
- Molecular Weight:504.99
IUPAC Name: N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)phenyl)methanesulfonamide
InChIKey: CLGWUCNXOBLWFM-UHFFFAOYSA-N
SMILES: CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O
Biological Activity: CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CZC-54252 | 98.05% | CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. CZC-54252 attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of ~1 nM. CZC-54252 has a neuroprotective activity. | ||||||||||||||||||||
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References
Keywords
