1192023-11-2
Chemical Structure
PTP peptide
- CAS No.: 1192023-11-2
- Formula:C36H64N8O10
- Molecular Weight:768.94
InChIKey: SRCAXFQAGIPODN-XNBZBTIXSA-N
SMILES: O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Biological Activity: PTP peptide is a specific Plectin-1 binder. PTP peptide can serve as a component of imaging agents; when conjugated with magnetofluorescent nanoparticles, it enables the detection of small pancreatic ductal adenocarcinomas and precancerous lesions via in vivo confocal microscopy and MRI. When conjugated with imaging agents, PTP peptide specifically targets pancreatic ductal adenocarcinoma cells, and can be used for tumor visualization and compound delivery. PTP peptide is applicable to research related to pancreatic ductal adenocarcinoma[1][2][3].
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PTP peptide | PTP peptide is a specific Plectin-1 binder. PTP peptide can serve as a component of imaging agents; when conjugated with magnetofluorescent nanoparticles, it enables the detection of small pancreatic ductal adenocarcinomas and precancerous lesions via in vivo confocal microscopy and MRI. When conjugated with imaging agents, PTP peptide specifically targets pancreatic ductal adenocarcinoma cells, and can be used for tumor visualization and compound delivery. PTP peptide is applicable to research related to pancreatic ductal adenocarcinoma. | |||||||||||||||||||||
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- [1]. Wang T, et al. Radiosynthesis and Preclinical Evaluation of [Ga]Ga-NOTA-PTP Profiling Plectin-1 Expression for Pancreatic Cancer Imaging. Journal of medicinal chemistry. 2026 Feb 12;69(3):2888-2899. [Content Brief]
- [2]. Kelly KA, et al. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS medicine. 2008 Apr 15;5(4):e85. [Content Brief]
- [3]. Zhou L, et al. Active-Targeted ICG for Surgical Navigation and Fluorescence-Guided Laparoscopic Photothermal Ablation in Pancreatic Ductal Adenocarcinoma. Analytical chemistry. 2025 Jan 14;97(1):473-481. [Content Brief]
Keywords
