1192754-07-6
Chemical Structure
BPR1K653 hydrochloride
- CAS No.: 1192754-07-6
- Formula:C30H30Cl2N6O2
- Molecular Weight:577.50
IUPAC Name: 1-(4-(2-((5-chloro-6-phenylfuro[2,3-d]pyrimidin-4-yl)amino)ethyl)phenyl)-3-(2-((dimethylamino)methyl)phenyl)urea hydrochloride
InChIKey: MGADTOAYEVRFIU-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C=C1)CCNC2=C3C(OC(C4=CC=CC=C4)=C3Cl)=NC=N2)NC5=CC=CC=C5CN(C)C.Cl
Biological Activity: BPR1K653 hydrochloride is a pan-Aurora kinase inhibitor, with an IC50 of 124.0 nM against Aurora-A and an IC50 of 45.0 nM against Aurora-B. BPR1K653 hydrochloride induces endoreduplication, apoptosis and antiproliferative activity in cancer cells. BPR1K653 hydrochloride can be used in research related to colon cancer and multidrug-resistant cancers[1][2].
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BPR1K653 hydrochloride | BPR1K653 hydrochloride is a pan-Aurora kinase inhibitor, with an IC50 of 124.0 nM against Aurora-A and an IC50 of 45.0 nM against Aurora-B. BPR1K653 hydrochloride induces endoreduplication, apoptosis and antiproliferative activity in cancer cells. BPR1K653 hydrochloride can be used in research related to colon cancer and multidrug-resistant cancers. | |||||||||||||||||||||
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References
- [1]. Ke YY, et al. Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition. European journal of medicinal chemistry. 2018 May 10;151:533-545.
- [2]. Cheung CH, et al. BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells. PloS one. 2011;6(8):e23485.
