119630-94-3
Chemical Structure
Naloxone benzoylhydrazone
Synonym(s): NalBzoH
- CAS No.: 119630-94-3
- Formula:C26H27N3O4
- Molecular Weight:445.51
IUPAC Name: N'-((4R,4aS,7aR,12bS,E)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-ylidene)benzohydrazide
InChIKey: AKXCFAYOTIEFOH-XTNAHFASSA-N
SMILES: O[C@]12[C@@]34C5=C(C(O)=CC=C5C[C@@]2([H])N(CC=C)CC4)O[C@@]3([H])/C(CC1)=N/NC(C6=CC=CC=C6)=O
Biological Activity: Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptors. Naloxone benzoylhydrazone has potently analgesia effect[1][2][3].
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Naloxone benzoylhydrazone | 98.36% | Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptors. Naloxone benzoylhydrazone has potently analgesia effect. | ||||||||||||||||||||
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- [1]. Olianas MC, et al. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br J Pharmacol. 2006 Feb;147(4):360-70. [Content Brief]
- [2]. Connor M, et al. Has the sun set on kappa3-opioid receptors? Br J Pharmacol. 2006 Feb;147(4):349-50. [Content Brief]
- [3]. Paul D, et al. Naloxone benzoylhydrazone (NalBzoH) analgesia. J Pharmacol Exp Ther. 1990 Nov;255(2):769-74. [Content Brief]
Keywords
