119934-51-9
119934-51-9
Chemical Structure
Niguldipine monohydrochloride
- CAS No.: 119934-51-9
- Formula:C36H40ClN3O6
- Molecular Weight:646.17
IUPAC Name: 3-(3-(4,4-diphenylpiperidin-1-yl)propyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
InChIKey: MHOSUIMBPQVOEU-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.Cl
Biological Activity: Niguldipine monohydrochloride is a calcium channel blocker that inhibits P-glycoprotein and can be used in tumor research. Niguldipine monohydrochloride inhibits Cav 3.2, with an IC50 of 0.9 μM[1][2].
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Niguldipine monohydrochloride | Niguldipine monohydrochloride is a calcium channel blocker that inhibits P-glycoprotein and can be used in tumor research. Niguldipine monohydrochloride inhibits Cav 3.2, with an IC50 of 0.9 μM. | |||||||||||||||||||||
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References
- [1]. Xiao-Fei Zhou, et al. New 4-aryl-1,4-dihydropyridines and 4-arylpyridines as P-glycoprotein inhibitors. Drug Metab Dispos. 2005 Mar;33(3):321-8. [Content Brief]
- [2]. John J Enyeart, et al. Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion. Am J Physiol Cell Physiol. 2015 Mar 18;308(11):C899–C918.
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