1246566-47-1
Chemical Structure
YLT192
- CAS. Nr.: 1246566-47-1
- Formula:C21H19N3O4
- Molecular Weight:377.39
IUPAC Name: 4-(4-(3-methoxybenzamido)phenoxy)-N-methylpicolinamide
InChIKey: VEAFCVREGPWSCO-UHFFFAOYSA-N
SMILES: O=C(NC)C1=NC=CC(OC2=CC=C(C=C2)NC(C3=CC=CC(OC)=C3)=O)=C1
Biological Activity: YLT192 is an orally active and highly bioavailable VEGFR2 inhibitor with potent anti-angiogenic activity and anti-tumor efficacy. YLT192 significantly inhibited the kinase activity of VEGFR2 and inhibited the proliferation, migration, invasion and tube formation of human umbilical cord vascular endothelial cells. YLT192 also inhibited VEGF-induced VEGFR2 phosphorylation and its downstream signaling regulators. YLT192 also showed the ability to inhibit angiogenesis in vivo in zebrafish embryo models and alginate-coated tumor cell experiments. YLT192 can directly inhibit the proliferation of cancer cells and induce their apoptosis[1].
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YLT192 | YLT192 is an orally active and highly bioavailable VEGFR2 inhibitor with potent anti-angiogenic activity and anti-tumor efficacy. YLT192 significantly inhibited the kinase activity of VEGFR2 and inhibited the proliferation, migration, invasion and tube formation of human umbilical cord vascular endothelial cells. YLT192 also inhibited VEGF-induced VEGFR2 phosphorylation and its downstream signaling regulators. YLT192 also showed the ability to inhibit angiogenesis in vivo in zebrafish embryo models and alginate-coated tumor cell experiments. YLT192 can directly inhibit the proliferation of cancer cells and induce their apoptosis. | |||||||||||||||||||||
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Keywords
