125455-61-0
Chemical Structure
H-Gly-Arg-pNA hydrochloride
Synonym(s): Gly-Arg-4-NA hydrochloride; GR-pNA hydrochloride; GR p-itoailide hydrochloride
- CAS No.: 125455-61-0
- Formula:C14H23Cl2N7O4
- Molecular Weight:424.28
IUPAC Name: (S)-2-(2-aminoacetamido)-5-guanidino-N-(4-nitrophenyl)pentanamide dihydrochloride
InChIKey: UMNMBKCWESYUMR-IDMXKUIJSA-N
SMILES: O=C([C@@H](NC(CN)=O)CCCNC(N)=N)NC(C=C1)=CC=C1[N+]([O-])=O.Cl.Cl
Biological Activity: H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity[1].
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H-Gly-Arg-pNA hydrochloride | H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity. | |||||||||||||||||||||
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Keywords
