1258783-03-7
Chemical Structure
Chondrocyte-affinity peptide
Synonym(s): CAP
- CAS No.: 1258783-03-7
- Formula:C65H103N19O16
- Molecular Weight:1406.63
InChIKey: DLHDYKZDCRZJSX-NMKOMOBXSA-N
SMILES: O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N5[C@@H](CCC5)C(N[C@@H](CO)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Biological Activity: Chondrocyte‑affinity peptide (CAP) is a dodecapeptide that exhibits targeted binding activity toward chondrocytes and can penetrate the dense cartilage matrix. Conjugation of Chondrocyte‑affinity peptide with polyethyleneimine (PEI) mediates the enrichment of gene vectors in chondrocytes. Chondrocyte‑affinity peptide can be applied in research related to targeted drug delivery to chondrocytes[1][2].
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Chondrocyte-affinity peptide | Chondrocyte‑affinity peptide (CAP) is a dodecapeptide that exhibits targeted binding activity toward chondrocytes and can penetrate the dense cartilage matrix. Conjugation of Chondrocyte‑affinity peptide with polyethyleneimine (PEI) mediates the enrichment of gene vectors in chondrocytes. Chondrocyte‑affinity peptide can be applied in research related to targeted drug delivery to chondrocytes. | |||||||||||||||||||||
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References
- [1]. Pi Y, et al. Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display. Biomaterials. 2011 Sep;32(26):6324-32.
- [2]. Liang Y, et al. Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment. Theranostics. 2022;12(11):4866-4878.
