1261394-20-0
1261394-20-0
Chemical Structure
Donepezil-d7 hydrochloride
Synonym(s): E2020-d7
- CAS No.: 1261394-20-0
- Formula:C24H23D7ClNO3
- Molecular Weight:423.00
IUPAC Name: 5,6-dimethoxy-2-((1-((phenyl-d5)methyl-d2)piperidin-4-yl)methyl)-2,3-dihydro-1H-inden-1-one hydrochloride
InChIKey: XWAIAVWHZJNZQQ-KABCIJOFSA-N
SMILES: O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)C([2H])([2H])C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H].Cl
Biological Activity: Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
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Donepezil-d7 hydrochloride | 99.0% | Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil Hydrochloride (Standard) | ≥98% | Donepezil (Hydrochloride) (Standard) is the analytical standard of Donepezil (Hydrochloride). This product is intended for research and analytical applications. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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Donepezil-d5 hydrochloride | 99.27% | Donepezil-d5 (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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Donepezil-d4 hydrochloride | 99.96% | Donepezil-d4 (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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Donepezil Hydrochloride | 99.92% | Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity. | ||||||||||||||||||||
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References
