1276197-53-5
1276197-53-5
Chemical Structure
Duloxetine-d5 oxalate
Synonym(s): (S)-Duloxetine-d5 oxalate; LY248686-d5 oxalate
- CAS No.: 1276197-53-5
- Formula:C20H16D5NO5S
- Molecular Weight:392.48
InChIKey: NMLRFGBDXFMJJM-SGFDQAQSSA-N
SMILES: OC(C(O)=O)=O.[2H]C([2H])([2H])NC([2H])([2H])C[C@@H](C1=CC=CS1)OC2=CC=CC3=C2C=CC=C3
Biological Activity: Duloxetine-d5 (oxalate) ((S)-Duloxetine-d5 (oxalate)) is deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
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Duloxetine-d5 oxalate | Duloxetine-d5 (oxalate) ((S)-Duloxetine-d5 (oxalate)) is deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). | |||||||||||||||||||||
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Duloxetine-d7 | Duloxetine-d7 ((S)-Duloxetine-d7) is the deuterium labeled Duloxetine. Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). | |||||||||||||||||||||
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Duloxetine | 99.92% | Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD). | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23(2): p. 417-22. [Content Brief]
