131190-63-1
131190-63-1
Chemical Structure
Saintopin
Synonym(s): UCT-1003
- CAS No.: 131190-63-1
- Formula:C18H10O7
- Molecular Weight:338.27
IUPAC Name: 1,3,8,10,11-pentahydroxytetracene-5,12-dione
InChIKey: CGFVUVWMYIHGHS-UHFFFAOYSA-N
SMILES: O=C(C1=CC(O)=CC(O)=C1C2=O)C3=C2C(O)=C4C(O)=CC(O)=CC4=C3
Biological Activity: Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage[1][2].
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Saintopin | Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage. | |||||||||||||||||||||
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References
- [1]. Yamashita Y, et al. Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces. J Antibiot (Tokyo). 1990 Oct;43(10):1344-6. [Content Brief]
- [2]. eteurtre F, et al. Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions. J Biol Chem. 1994 Nov 18;269(46):28702-7. [Content Brief]
Keywords
