1313731-99-5
1313731-99-5
Chemical Structure
TGN-020 sodium
- CAS No.: 1313731-99-5
- Formula:C8H5N4NaOS
- Molecular Weight:228.21
IUPAC Name: sodium nicotinoyl(1,3,4-thiadiazol-2-yl)amide
InChIKey: YVHWOCDMDRVSHB-UHFFFAOYSA-M
SMILES: O=C(C1=CC=CN=C1)[N-]C2=NN=CS2.[Na+]
Biological Activity: TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TGN-020 sodium | 99.96% | TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats. | ||||||||||||||||||||
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References
- [1]. Vincent J Huber, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7. [Content Brief]
- [2]. Shou Oosuka, et al. Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina. Int J Mol Sci. 2020 Mar 27;21(7):2324. [Content Brief]
- [3]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]
- [4]. Jian Li, et al. TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats. Life Sci. 2019 Apr 1;222:148-157. [Content Brief]
Keywords
