1314140-00-5
1314140-00-5
Chemical Structure
TC-N 22A
- CAS No.: 1314140-00-5
- Formula:C14H13N5S
- Molecular Weight:283.35
IUPAC Name: N-(pyridin-2-yl)-4,5,6,8-tetrahydropyrazolo[3',4':6,7]cyclohepta[1,2-d]thiazol-2-amine
InChIKey: DBISXWCOHGUFSF-UHFFFAOYSA-N
SMILES: C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1
Biological Activity: TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].
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TC-N 22A | TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo. | |||||||||||||||||||||
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References
Keywords
