1330624-42-4
1330624-42-4
Chemical Structure
VU0418506
- CAS No.: 1330624-42-4
- Formula:C12H8ClFN4
- Molecular Weight:262.67
IUPAC Name: N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine
InChIKey: SBDWTBISUBYOMI-UHFFFAOYSA-N
SMILES: FC1=CC=C(NC2=NNC3=C2N=CC=C3)C=C1Cl
Biological Activity: VU0418506 is a selective positive allosteric modulator of mGlu4, with EC50 values of 68 nM and 46 nM for hmGlu4 and rmGlu4, respectively. VU0418506 exhibits antiparkinsonian activity[1][2].
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VU0418506 | VU0418506 is a selective positive allosteric modulator of mGlu4, with EC50 values of 68 nM and 46 nM for hmGlu4 and rmGlu4, respectively. VU0418506 exhibits antiparkinsonian activity. | |||||||||||||||||||||
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References
- [1]. Darren W Engers, et al. Discovery, Synthesis, and Preclinical Characterization of N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu4). ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200. [Content Brief]
- [2]. Colleen M Niswender, et al. Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. [Content Brief]
Keywords
