133983-25-2
Chemical Structure
SQ-33600
- CAS No.: 133983-25-2
- Formula:C23H21FNNa2O5P
- Molecular Weight:487.37
IUPAC Name: sodium (S)-4-(((1-(4-fluorophenyl)-3-isopropyl-1H-indol-2-yl)ethynyl)oxidophosphoryl)-3-hydroxybutanoate
InChIKey: FXHKSTYWSZZOBF-NTEVMMBTSA-L
SMILES: O=C(C[C@@H](CP(C#CC(N1C2=CC=C(C=C2)F)=C(C3=C1C=CC=C3)C(C)C)(O[Na])=O)O)O[Na]
Biological Activity: SQ-33600 is an HMG-CoA reductase inhibitor. SQ-33600 has cholesterol-lowering activity. SQ-33600 possesses cell-type selectivity, with much higher inhibitory activity on rat hepatocytes (IC50: 93 nM) than on human skin fibroblasts (IC50: 14200 nM). SQ-33600 can be used in the research of diseases such as hypercholesterolemia[1][2].
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SQ-33600 | SQ-33600 is an HMG-CoA reductase inhibitor. SQ-33600 has cholesterol-lowering activity. SQ-33600 possesses cell-type selectivity, with much higher inhibitory activity on rat hepatocytes (IC50: 93 nM) than on human skin fibroblasts (IC50: 14200 nM). SQ-33600 can be used in the research of diseases such as hypercholesterolemia. | |||||||||||||||||||||
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- [1]. Wang-Iverson D, et al. Determination of SQ 33,600, a phosphinic acid containing HMG CoA reductase inhibitor, in human serum by high-performance liquid chromatography combined with ionspray mass spectrometry. Biol Mass Spectrom. 1992 Apr;21(4):189-94. [Content Brief]
- [2]. Jagoda E, et al. Radioimmunoassay for hydroxyphosphinyl-3-hydroxybutanoic acid (SQ 33,600), a hypocholesterolemia agent. Ther Drug Monit. 1993 Jun;15(3):213-9. [Content Brief]
Keywords
