134335-45-8
Chemical Structure
P15
- CAS No.: 134335-45-8
- Formula:C59H100N20O19
- Molecular Weight:1393.55
InChIKey: NSBMKIFBUPCNBV-PTCABIDGSA-N
SMILES: O=C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(NCC(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN
Biological Activity: P15 is a type I collagen-mimetic peptide with pro-adhesive properties. P15 binds to membrane integrin, including α2β1, to mediate cell adhesion and trigger the production of growth factors and cytokines. P15 upregulates the expression of osteogenic genes via targets including RUNX2, OSTRX and BSP. P15 stimulates the adhesion and proliferation of osteoblasts, enhances alkaline phosphatase activity and calcium deposition, and supports osteogenic differentiation. P15 can be used in research related to periodontal bone defects, cervical intervertebral disc defects, and non-union/bone defects[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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P15 | 99.46% | P15 is a type I collagen-mimetic peptide with pro-adhesive properties. P15 binds to membrane integrin, including α2β1, to mediate cell adhesion and trigger the production of growth factors and cytokines. P15 upregulates the expression of osteogenic genes via targets including RUNX2, OSTRX and BSP. P15 stimulates the adhesion and proliferation of osteoblasts, enhances alkaline phosphatase activity and calcium deposition, and supports osteogenic differentiation. P15 can be used in research related to periodontal bone defects, cervical intervertebral disc defects, and non-union/bone defects. | ||||||||||||||||||||
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- [1]. Klimek K, et al. Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications-A Review. Polymers. 2020 Apr 06;12(4):844. [Content Brief]
- [2]. Wang Z, et al. Improved Cell Adhesion and Osteogenesis of op-HA/PLGA Composite by Poly(dopamine)-Assisted Immobilization of Collagen Mimetic Peptide and Osteogenic Growth Peptide. ACS applied materials & interfaces. 2016 Oct 12;8(40):26559-26569. [Content Brief]
- [3]. Bullock G, et al. Osteogenic Peptides and Attachment Methods Determine Tissue Regeneration in Modified Bone Graft Substitutes. Journal of functional biomaterials. 2021 Mar 31;12(2):22. [Content Brief]
Keywords
