1346599-65-2
Chemical Structure
Phentolamine-d4 hydrochloride
- CAS No.: 1346599-65-2
- Formula:C17H16D4ClN3O
- Molecular Weight:285.38
IUPAC Name: 3-(((4,5-dihydro-1H-imidazol-2-yl-4,4,5,5-d4)methyl)(p-tolyl)amino)phenol hydrochloride
InChIKey: TUEJFGFQYKDAPM-PQDNHERISA-N
SMILES: N(CC=1NC(C(N1)([2H])[2H])([2H])[2H])(C2=CC(O)=CC=C2)C3=CC=C(C)C=C3.Cl
Biological Activity: Phentolamine-d4 (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].
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Phentolamine-d4 hydrochloride | Phentolamine-d4 (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction. | |||||||||||||||||||||
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Phentolamine hydrochloride (Standard) | ≥98% | Phentolamine (hydrochloride) (Standard) is the analytical standard of Phentolamine (hydrochloride). This product is intended for research and analytical applications. Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent. | ||||||||||||||||||||
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Phentolamine hydrochloride | 99.91% | Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Gould L, et, al. Phentolamine. Am Heart J. 1976 Sep;92(3):397-402. [Content Brief]
- [3]. Goldstein I, et, al. Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res. 2000 Mar;12 Suppl 1:S75-80. [Content Brief]
