1360821-61-9
Chemical Structure
RO5353
- CAS. Nr.: 1360821-61-9
- Formula:C29H29Cl2FN4O4S
- Molecular Weight:619.53
IUPAC Name: (2S,3R,4R,5R)-N-(4-carbamoyl-2-methoxyphenyl)-2'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-5'-oxo-4',5'-dihydrospiro[pyrrolidine-3,6'-thieno[3,2-b]pyrrole]-5-carboxamide
InChIKey: UOVSZRTTWLJPHE-HNXAPSNLSA-N
SMILES: NC(C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@@]4(C(SC(Cl)=C5)=C5NC4=O)[C@H](CC(C)(C)C)N2)=O)C=C1)=O
Biological Activity: RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice[1].
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RO5353 | RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice. | |||||||||||||||||||||
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Keywords
