1370256-78-2
1370256-78-2
Chemical Structure
SKLB4771
Synonym(s): FLT3-IN-1
- CAS No.: 1370256-78-2
- Formula:C25H27N7O3S2
- Molecular Weight:537.66
IUPAC Name: 1-(5-((7-(3-morpholinopropoxy)quinazolin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(p-tolyl)urea
InChIKey: LKXFSTAQMOENSC-UHFFFAOYSA-N
SMILES: O=C(NC1=NN=C(SC2=C3C=CC(OCCCN4CCOCC4)=CC3=NC=N2)S1)NC5=CC=C(C)C=C5
Biological Activity: SKLB4771 is a potent and selective Flt3 inhibitor with an IC50 value of 10 nM. SKLB4771 downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SKLB4771 | 99.20% | SKLB4771 is a potent and selective Flt3 inhibitor with an IC50 value of 10 nM. SKLB4771 downregulates the phosphorylation of FLT3/STAT5/ERK, blocks cell proliferation, and induces apoptosis in tumor tissue. | ||||||||||||||||||||
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References
- [1]. Li WW, et al. Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo. J Med Chem. 2012 Apr 26;55(8):3852-66. [Content Brief]
- [2]. Yan HX, et al. Accumulation of FLT3(+) CD11c (+) dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor. Immunol Res. 2014 Oct;60(1):112-26. [Content Brief]
Keywords
