1394808-20-8
Chemical Structure
Samelisant
Synonym(s): SUVN-G3031
- CAS No.: 1394808-20-8
- Formula:C21H33Cl2N3O3
- Molecular Weight:446.41
IUPAC Name: N-(4-((1-cyclobutylpiperidin-4-yl)oxy)phenyl)-2-morpholinoacetamide dihydrochloride
InChIKey: LCPQCTBHZPMVFX-UHFFFAOYSA-N
SMILES: O=C(CN1CCOCC1)NC2=CC=C(C=C2)OC3CCN(CC3)C4CCC4.[H]Cl.[H]Cl
Biological Activity: Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant can be used for the research of sleep-related disorders[1].
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Samelisant | 98.65% | Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant can be used for the research of sleep-related disorders. | ||||||||||||||||||||
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Keywords
