140637-82-7
Chemical Structure
Galarubicin hydrochloride
Synonym(s): DA 125
- CAS No.: 140637-82-7
- Formula:C30H33ClFNO13
- Molecular Weight:670.03
IUPAC Name: 2-((2S,4S)-4-(((2R,3R,4R,5S,6S)-3-fluoro-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)-2-oxoethyl 3-aminopropanoate hydrochloride
InChIKey: PISPJMVXLMWWNB-ZZBYHBTRSA-N
SMILES: F[C@H]([C@@H]([C@H](O)[C@H](C)O1)O)[C@]1([H])O[C@@H]2C3=C(O)C(C(C4=C(OC)C=CC=C4C5=O)=O)=C5C(O)=C3C[C@](C(COC(CCN)=O)=O)(O)C2.Cl
Biological Activity: Galarubicin hydrochloride (DA 125) is a novel Anthracycline derivative. Galarubicin hydrochloride shows high-affinity DNA binding and topoisomerase II inhibitory activities. Galarubicin hydrochloride induces Apoptosis. Galarubicin hydrochloride exerts cytotoxicity via JNK pathway. Galarubicin hydrochloride can be used in the research of hepatocellular carcinoma[1].
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Galarubicin hydrochloride | Galarubicin hydrochloride (DA 125) is a novel Anthracycline derivative. Galarubicin hydrochloride shows high-affinity DNA binding and topoisomerase II inhibitory activities. Galarubicin hydrochloride induces Apoptosis. Galarubicin hydrochloride exerts cytotoxicity via JNK pathway. Galarubicin hydrochloride can be used in the research of hepatocellular carcinoma. | |||||||||||||||||||||
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Keywords
