141979-19-3
Chemical Structure
16-Hydroxycleroda-3,13-dien-15,16-olide
Synonym(s): 16ξ-Hydroxycleroda-3,13-dien-15,16-olide
- CAS No.: 141979-19-3
- Formula:C20H30O3
- Molecular Weight:318.45
IUPAC Name: 5-hydroxy-4-(2-((1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl)ethyl)furan-2(5H)-one
InChIKey: LVSCWEDTMWAASP-RQRNCZJESA-N
SMILES: OC(O1)C(CC[C@@]2([C@]3([H])[C@@](CC[C@H]2C)(C(C)=CCC3)C)C)=CC1=O
Biological Activity: 16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].
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16-Hydroxycleroda-3,13-dien-15,16-olide | 16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy. | |||||||||||||||||||||
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