1425511-32-5
Chemical Structure
Luvadaxistat
Synonym(s): TAK-831
- CAS No.: 1425511-32-5
- Formula:C13H11F3N2O2
- Molecular Weight:284.23
IUPAC Name: 4-hydroxy-6-(4-(trifluoromethyl)phenethyl)pyridazin-3(2H)-one
InChIKey: QBQMUMMSYHUDFM-UHFFFAOYSA-N
SMILES: O=C1C(O)=CC(CCC2=CC=C(C(F)(F)F)C=C2)=NN1
Biological Activity: Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Luvadaxistat | 99.08% | Luvadaxistat (TAK-831) is an orally active, highly selective, potent D-amino acid oxidase (DAAO) inhibitor. Luvadaxistat inhibits oxidative deamination of D-serine via the human recombinant DAAO enzyme with an IC50 of 14 nM. Luvadaxistat significantly increases D-serine levels in the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat has the potential for schizophrenia research. | ||||||||||||||||||||
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- [1]. Rosa Fradley, et al. Luvadaxistat: A Novel Potent and Selective D-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia. [Content Brief]
- [2]. Wang H, Norton J, Xu L, DeMartinis N, Sen R, Shah A, Farmer J, Lynch D. Results of a randomized double-blind study evaluating luvadaxistat in adults with Friedreich ataxia. Ann Clin Transl Neurol. 2021 Jun;8(6):1343-1352. [Content Brief]
Keywords
