1426240-47-2
Chemical Structure
(R,R,S)-GAT107
- CAS No.: 1426240-47-2
- Formula:C18H17BrN2O2S
- Molecular Weight:405.31
InChIKey: YNCXHXYZTLIZTO-VKJFTORMSA-N
SMILES: NS(=O)(C1=CC=C2N[C@@H](C3=CC=C(C=C3)Br)[C@](CC=C4)([H])[C@]4([H])C2=C1)=O
Biological Activity: (R,R,S)-GAT107 is a fully agonistic positive modulator of α7 nicotinic receptors with significant biological activity. Its activity is entirely present in its (+)-isomer 1b, while (-)-isomer 1a does not affect its activity when used together. Studies have shown that (R,R,S)-GAT107 is the most potent ago-PAM for α7 nicotinic receptors currently known and has the potential for further in vivo evaluation[1].
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(R,R,S)-GAT107 | (R,R,S)-GAT107 is a fully agonistic positive modulator of α7 nicotinic receptors with significant biological activity. Its activity is entirely present in its (+)-isomer 1b, while (-)-isomer 1a does not affect its activity when used together. Studies have shown that (R,R,S)-GAT107 is the most potent ago-PAM for α7 nicotinic receptors currently known and has the potential for further in vivo evaluation. | |||||||||||||||||||||
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Keywords
