1429192-00-6
1429192-00-6
Chemical Structure
Retro-2 cycl
Synonym(s): RN 1-001
- CAS No.: 1429192-00-6
- Formula:C19H16N2OS
- Molecular Weight:320.41
IUPAC Name: 2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
InChIKey: BOAPXDSRULBILC-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2NC(N1C3=CC=CC=C3)C4=CC=C(S4)C
Biological Activity: Retro-2 cycl (RN 1-001) is a retrograde transport inhibitor with antiviral activity. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudoviruses, with an IC50 of 54 μM and 160 μM respectively[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Retro-2 cycl | 99.17% | Retro-2 cycl (RN 1-001) is a retrograde transport inhibitor with antiviral activity. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudoviruses, with an IC50 of 54 μM and 160 μM respectively. | ||||||||||||||||||||
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References
- [1]. Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22(17):4836-47. [Content Brief]
- [2]. Wen Dai, et al. Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro. J Microbiol Biotechnol. 2018 Jun 28;28(6):849-859. [Content Brief]
- [3]. Wenwen Dai, et al. Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug:144:311-321. [Content Brief]
Keywords
