1431553-15-9
Chemical Structure
TRC210258
- CAS No.: 1431553-15-9
- Formula:C20H14ClFN4O2
- Molecular Weight:396.80
IUPAC Name: N-(4-chlorophenyl)-2-(4-fluorophenoxy)-N-methylimidazo[1,2-a]pyrimidine-3-carboxamide
InChIKey: POBOMPHQSJGCGZ-UHFFFAOYSA-N
SMILES: O=C(N(C)C1=CC=C(C=C1)Cl)C2=C(N=C3N=CC=CN32)OC4=CC=C(C=C4)F
Biological Activity: TRC210258 is a TGR5 agonist with activity to improve diabetes-associated hyperglycemia and dyslipidemia. TRC210258 promotes energy expenditure by enhancing the release of glucagon-like peptide-1. TRC210258 is able to improve glucose metabolic control in high-fat diet-induced obese mice. TRC210258 also showed improvement in lipid parameters in high-fat-fed hamsters, including reductions in plasma triglyceride and low-density lipoprotein cholesterol levels. TRC210258 improved emerging lipid-related cardiovascular risk parameters including remnant cholesterol and triglyceride clearance[1].
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TRC210258 | 99.55% | TRC210258 is a TGR5 agonist with activity to improve diabetes-associated hyperglycemia and dyslipidemia. TRC210258 promotes energy expenditure by enhancing the release of glucagon-like peptide-1. TRC210258 is able to improve glucose metabolic control in high-fat diet-induced obese mice. TRC210258 also showed improvement in lipid parameters in high-fat-fed hamsters, including reductions in plasma triglyceride and low-density lipoprotein cholesterol levels. TRC210258 improved emerging lipid-related cardiovascular risk parameters including remnant cholesterol and triglyceride clearance. | ||||||||||||||||||||
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Keywords
